The pleasure war of devils intensifies! Targeted Sisters! An elite career investigator, Mio, is administered the most terrifying and obscene aphrodisiac in human history, created by the Institute of Female Torture, and undergoes unimaginable brutal torture in front of her real sister. Mio wanders between madness and pleasure. On the other hand, Himekawa and other female investigators also tremble with anger at the declaration of war by the research institute. How will this endless battle go? The final countdown to the end of the complex story of a man and a woman begins...